The Intracellular Localization of ID2 Expression Has a Predictive Value in Non Small Cell Lung Cancer

Jérôme Rollin (1) , Claire Bléchet (2, 3) , Sandra Régina (2, 4) , Arthur Tenenhaus (1, 5) , Serge Guyétant (2, 3) , Xavier Gidrol (1)

1 LEFG - Laboratoire d'Exploration Fonctionnelle des Génomes
2 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie
3 Laboratoire d'anatomie pathologique
4 service d'hématologie-hémostase
5 E3S - Supélec Sciences des Systèmes

ID2 is a member of a subclass of transcription regulators belonging to the general bHLH (basic-helix-loophelix) family of transcription factors. In normal cells, ID2 is responsible for regulating the balance between proliferation and differentiation. More recent studies have demonstrated that ID2 is involved in tumor progression in several cancer types such as prostate or breast.

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]; Bio-informatique [q-bio.QM]

Jérôme Rollin, Claire Bléchet, Sandra Régina, Arthur Tenenhaus, Serge Guyétant, et al.. The Intracellular Localization of ID2 Expression Has a Predictive Value in Non Small Cell Lung Cancer. PLoS ONE, 2009, 4 (1), p. e4158 (7 p.). ⟨hal-00355599⟩