A new model for closed-loop control in type 1 diabetes
Résumé
A new control model for T1DM is designed with the aim to represent accurately the plasma glucose-insulin dynamics. It is in the form of a nonlinear system of three timecontinuous state equations. The model includes two successive remote compartments for plasma insulin, accounting for a slow and a fast dynamics. The modeling of the action of the insulin on the glucose disappearance is in an original nonlinear form. This new model is identified and validated using data from the adult subjects of the UVa T1DM simulator training database. The parametric identification of the model provides in each case an accurate representation of the glucose-insulin dynamics of the subjects.