A new closed-loop strategy for the treatment of type 1 diabetes based on Error Dynamics Shaping
Abstract
The present study evaluates Error Dynamics Shaping (EDS) as an alternative closed-loop strategy for subcutaneous insulin delivery in type 1 diabetes. EDS uses the energy-based principle of damping to ensure a robust stability of closed-loop systems. It benefits from intuitive tuning criteria and provides explicit state feedback control laws requiring few computational resources. Using FDA approved UVaT1DM simulator, EDS robustness against meal profile variability was tested. The percentage of time spent with blood glucose in the 70-150 mg/dl range was 89.7%. No hypoglycemia (<60mg/dl) was recorded. In silico, EDS controller is effective in achieving normoglycemia and robust to meal disturbances.