Optogenetics to Unravel the Mechanisms of Parkinsonian Symptoms and Optimize Deep Brain Stimulation

Antoine Chaillet (1) , Diane da Silva (1) , Georgios Is Detorakis (1) , Suhan Senova (2)

1 L2S - Laboratoire des signaux et systèmes
2 Service de neuro-chirurgie

By allowing a precise stimulation of targeted neurons through light impulses, optogenetics is revolutionizing our understanding of the brain. Its recent use in primate deep brain structures promises unprecedented data to model the mechanisms underlying Parkinson’s disease symptoms and to improve their treatment by electrical stimulation.

Keywords: Optogenetics; Parkinson Disease; DBS

Domains: Engineering Sciences [physics]; Automatic; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]

Antoine Chaillet, Diane da Silva, Georgios Is Detorakis, Suhan Senova. Optogenetics to Unravel the Mechanisms of Parkinsonian Symptoms and Optimize Deep Brain Stimulation. ERCIM News, 2014, 17, pp.1-3. ⟨hal-01103325⟩