In Situ Monitoring of Cocrystallization Processes - Complementary Use of Sensing Technologies

Abstract : Two in situ process analytical technologies were used to investigate a cocrystallization process: a focused beam reflectance measurement probe and a video probe. The cocrystallizations were conducted batch-wise in a stirred thermostatted vessel with carbamazepine and nicotinamide. The experiments were started in three domains of the phase solubility diagram. When carbamazepine crystals were also formed, a solution mediated phase transition from carbamazepine crystals towards cocrystals was initiated by the addition of the cocrystallizing agent (nicotinamide crystals). As the carbamazepine crystals and the carbamazepine/nicotinamide cocrystals exhibit prism-like and needle-like habits, respectively, it was possible to discriminate between them with the two sensors. The mechanisms involved in the solution mediated phase transition were investigated.
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E. Gagniere, F. Puel, D. Mangin, J.-P. Valour, A. Rivoire, et al.. In Situ Monitoring of Cocrystallization Processes - Complementary Use of Sensing Technologies. Chemical Engineering and Technology, 2012, 35 (SI) (6), pp.1039-1044. ⟨10.1002/ceat.201100711⟩. ⟨hal-01271824⟩

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