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Neural Networks to Predict Survival from RNA-seq Data in Oncology

Abstract : Survival analysis consists of studying the elapsed time until an event of interest, such as the death or recovery of a patient in medical studies. This work explores the potential of neural networks in survival analysis from clinical and RNA-seq data. If the neural network approach is not recent in survival analysis, methods were classically considered for low-dimensional input data. But with the emergence of high-throughput sequencing data, the number of covariates of interest has become very large, with new statistical issues to consider. We present and test a few recent neural network approaches for survival analysis adapted to high-dimensional inputs.
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https://hal-centralesupelec.archives-ouvertes.fr/hal-03347253
Contributor : Mathilde Sautreuil Connect in order to contact the contributor
Submitted on : Friday, September 17, 2021 - 9:53:45 AM
Last modification on : Monday, December 13, 2021 - 9:17:24 AM

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Mathilde Sautreuil, Sarah Lemler, Paul-Henry Cournède. Neural Networks to Predict Survival from RNA-seq Data in Oncology. Computational Methods in Systems Biology, pp.122-140, 2021, ⟨10.1007/978-3-030-85633-5_8⟩. ⟨hal-03347253⟩

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