Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits

Matthieu Faillot (1) , Antoine Chaillet (2, 3) , Stéphane Palfi (1) , Suhan Senova (1)

1 CHU Henri Mondor [Créteil]
2 IUF - Institut universitaire de France
3 L2S - Laboratoire des signaux et systèmes

Deep brain stimulation paradigms might be used to treat memory disorders in patients with stroke or traumatic brain injury. However, proof of concept studies in animal models are needed before clinical translation. We propose here a comprehensive review of rodent models for Traumatic Brain Injury and Stroke. We systematically review the histological, behavioral and electrophysiological features of each model and identify those that are the most relevant for translational research.

Domaines: Neurosciences [q-bio.NC]; Automatique / Robotique

Matthieu Faillot, Antoine Chaillet, Stéphane Palfi, Suhan Senova. Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits. Neuroscience and Biobehavioral Reviews, 2021, 130, pp.410-432. ⟨10.1016/j.neubiorev.2021.08.012⟩. ⟨hal-03520529⟩