5-Fluoro-1,2,3-triazole motif in peptides and its electronic properties

José Laxio Arenas (1) , Pascal Retailleau (2) , Jean-Michel Gillet (3) , Nour-Eddine Ghermani (3, 4) , Sandrine Ongeri (1) , Benoît Crousse (1)

1 BioCIS - Biomolécules : Conception, Isolement, Synthèse
2 ICSN - Institut de Chimie des Substances Naturelles
3 SPMS - Laboratoire Structures, Propriétés et Modélisation des solides
4 IGPS - Institut Galien Paris-Saclay

The 5-fluoro triazole amino acid has been prepared by halogen exchange between the 5-iodo triazole and fluoride salts and incorporated in peptides. X-ray crystallography reveals a cylindrical shape in its deformation electron density.

Domains: Chemical Sciences

José Laxio Arenas, Pascal Retailleau, Jean-Michel Gillet, Nour-Eddine Ghermani, Sandrine Ongeri, et al.. 5-Fluoro-1,2,3-triazole motif in peptides and its electronic properties. Organic & Biomolecular Chemistry, 2022, 20 (43), pp.8410-8414. ⟨10.1039/d2ob01716d⟩. ⟨hal-03903289⟩