Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1,2:1,2]imidazo[4,5-h]quinazolines

Marianne Dupuy , Frédéric Pinguet (1) , Olivier Chavignon (2) , Jean-Michel Chezal (3) , Jean-Claude Teulade (3) , Jean-Pierre Chapat , Yves Blache (4)

1 CRLCC Val d'Aurelle - Paul Lamarque
2 Etude Métabolique des Molécules Marquées
3 IMTV - Imagerie Moléculaire et Thérapie Vectorisée
4 MAPIEM - Laboratoire Matériaux Polymères Interfaces Environnement Marin - EA 4323

Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some “N-C-N” bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activitise on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena.

Domaines: Chimie organique; Chimie thérapeutique

Marianne Dupuy, Frédéric Pinguet, Olivier Chavignon, Jean-Michel Chezal, Jean-Claude Teulade, et al.. Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1,2:1,2]imidazo[4,5-h]quinazolines. Chemical and Pharmaceutical Bulletin, 2001, 49, pp.1061 - 1065. ⟨10.1248/cpb.49.1061⟩. ⟨hal-02384513⟩