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Experimental study of tensile strength of pharmaceutical tablets: effect of the diluent nature and compression pressure

Abstract : In the pharmaceutical field, tablets are the most common dosage form for oral administration in the world. Among different manufacturing processes, direct compression is widely used because of its economics interest and it is a process which avoids the steps of wet granulation and drying processes. Tablets are composed of at least two ingredients: an active pharmaceutical ingredient (API) which is mixed with a diluent. The nature of the powders and the processing conditions are crucial for the properties of the blend and, consequently, strongly influence the mechanical characteristics of tablets. Moreover, tablets have to present a suitable mechanical strength to avoid crumbling or breaking when handling, while ensuring an appropriate disintegration after administration. Accordingly, this mechanical property is an essential parameter to consider. Experimental results showed that proportion of the diluent, fragmentary (DCPA) or plastic (MCC), had a large influence on the tensile strength evolution with API content as well as the compression load applied during tableting process. From these results a model was developed in order to predict the tensile strength of binary tablets by knowing the compression pressure. The validity of this model was demonstrated for the two studied systems and a comparison was made with two existing models.
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Audrey Juban, Stephanie Briancon, François Puel, Thierry Hoc, Cécile Nouguier-Lehon. Experimental study of tensile strength of pharmaceutical tablets: effect of the diluent nature and compression pressure. Powders and Grains 2017 8th International Conference on Micromechanics of granular Media, Jul 2017, Montpellier, France. ⟨10.1051/epjconf/201714013002⟩. ⟨hal-01820525⟩



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