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Modélisation de l’effet de la rugosité sur l’adhésion d’ostéoblastes : application au titane

Abstract : An implant lifetime partly depends on the quality of the osseointegration. It has been established that osseointegration is influenced by treatments performed to shape and obtain the implants, throughout mechanical properties which can be modified in a given depth, as well as chemical and topographical properties. In order to predict the effect of a surface treatment on cellular behavior, a model has been elaborated to simulate cellular attachment on different titanium surfaces. This model is based on the space occupation of spherical cells randomly distributed on topographical profiles. The simulated design is then compared to in-vitro experiments with MG63 osteoblastical cells. The number of cells per square millimeter is calculated in each case; comparisons between experimental and theoretical results demonstrate the feasibility of reaching such parameter by modelling. Future developments of the model will allow to study cellular spreading, mechanical constraints, scale-dependent topographical parameters and surface chemical properties.
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Submitted on : Monday, December 21, 2015 - 4:02:35 PM
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Matthieu Lecomte, François Wenger, Pierre Ponthiaux, Veronique Migonney. Modélisation de l’effet de la rugosité sur l’adhésion d’ostéoblastes : application au titane. Matériaux & Techniques, EDP Sciences, 2010, 98 (1), pp.49-57. ⟨10.1051/mattech/2010018⟩. ⟨hal-01247277⟩



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