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Molecular resolution of a dioleoyl-Sn-glycero-phosphocholine lipid bilayer in liquid by phase modulation atomic force microscopy

Abstract : We present a molecular resolved image of a supported lipid bilayer using atomic force microscopy in liquid conditions. Due to the well-known molecular diffusion processes with velocities of a few nm/s occurring in free-standing membranes, this type of mapping is difficult to achieve. We have obtained a sub-nanometer scale resolution of a dioleoyl-sn-glycero-phosphocholine membrane because of the high sensitivity of our phase modulated microscope and the slowed down diffusion due to the interaction with the substrate. A pair function analysis has revealed local disordered and gel phases with an order range limited to the first neighbour.
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https://hal-centralesupelec.archives-ouvertes.fr/hal-01285851
Contributor : Sebastian Volz <>
Submitted on : Wednesday, March 9, 2016 - 6:40:55 PM
Last modification on : Wednesday, September 16, 2020 - 4:46:20 PM

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Antonin Hoël, Toshihisa Osaki, Shoji Takeuchi, Hideki Kawakatsu, Sebastian Volz. Molecular resolution of a dioleoyl-Sn-glycero-phosphocholine lipid bilayer in liquid by phase modulation atomic force microscopy. Applied Physics Letters, American Institute of Physics, 2012, 101 (6), pp.063117. ⟨10.1063/1.4745184⟩. ⟨hal-01285851⟩

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